Leishmaniaexpressed lipophosphoglycan interacts with Toll-like receptor (TLR)-2 to decrease TLR-9 expression and reduce anti-leishmanial responses
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Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects
OBJECTIVE Individuals with type 2 diabetes have a myriad of metabolic aberrations including increased inflammation, increasing their cardiovascular risk. Toll-like receptors (TLRs) and their ligands play a key role in insulin resistance and atherosclerosis. However, there is a paucity of data examining the expression and activity of TLRs in type 2 diabetes. Thus, in the present study, we examin...
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Address for correspondence: Michał Sobjanek MD, PhD, Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 1a Kliniczna St, 80-402 Gdansk, Poland, phone: +48 607 039 729, e-mail: [email protected] Received: 8.01.2016, accepted: 20.04.2016. The ethiopathogenesis of psoriasis is complex, multifactorial and still not well understood. Nowadays, the systemic, inflammator...
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Genetic host factors play a substantial role in susceptibility to and severity of malaria, which continues to cause at least one million deaths per year. Recently, members of the toll-like receptor (TLR) family have been shown to be involved in recognition of the etiologic organism Plasmodium falciparum: The glycosylphosphatidylinisitol anchor induces signaling in host cells via TLR-2 and -4, w...
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Immune cells express multiple Toll-like receptors (TLRs) that are concomitantly activated by a variety of pathogen products. Although there is presumably a need to coordinate the expression and function of TLRs in individual cells, little is known about the mechanisms governing this process. We show that a protein associated with TLR4 (PRAT4A) is required for multiple TLR responses. PRAT4A resi...
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Background: TLR2 SNPs are linked to tuberculosis but the mechanisms by which they alter TLR signaling are unclear Results: R753Q TLR2 showed impaired tyrosine phosphorylation, dimerization with TLR6, MyD88 recruitment, induction of NF-κB and cytokines upon mycobacterial challenge Conclusion: R753Q polymorphism blocks TLR2 tyrosine phosphorylation and signalosome assembly Significance: Decipheri...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2013
ISSN: 0009-9104
DOI: 10.1111/cei.12074